I own a Cameo (12" cut) and had varying degrees of success with it. The optical sensor that is supposed to find the registration marks automatically for print & cut is crap. It's very susceptible yo lighting conditions and often doesn't work at all on coloured media.
The cutting force of the Cameo is also very poor if cutting anything other than vinyl. The mat tends to slip in the rollers and it's very noisy. I got sick of wasting good, expensive materials in this machine and that's why I went for a Silver Bullet. You can cut many materials with a SB machine and you can also engrave and emboss with it. You've never really said what it is you want to do though so you'll not get very specific answers.